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Chemodex
Droperidol
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Product Details | |
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Synonyms | 1-[1-[3-(p-Fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone; NSC 169874 |
Product Type | Chemical |
Properties | |
Formula |
C22H22FN3O2 |
MW | 379.43 |
CAS | 548-73-2 |
RTECS | DE2100000 |
Purity Chemicals | ≥98% (TLC) |
Appearance | White to light yellow powder. |
Solubility | Soluble in DMSO (20mg/ml) or DMF (20mg/ml). |
Identity | Determined by 1H-NMR. |
Declaration | Manufactured by Chemodex. |
Other Product Data |
Click here for Original Manufacturer Product Datasheet |
InChi Key | RMEDXOLNCUSCGS-UHFFFAOYSA-N |
Smiles | O=C(C1=CC=C(F)C=C1)CCCN2CCC(N3C4=CC=CC=C4NC3=O)=CC2 |
Shipping and Handling | |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Protect from light and moisture. |
Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Documents | |
MSDS | Inquire |
Product Specification Sheet | |
Datasheet |
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Droperidol is a butyrophenone that acts as an antagonist at dopamine receptors D2 and D4. It less potently inhibits the human voltage-gated potassium channel, 5-HT, α-adrenergic and histamine receptors. Droperidol has been shown to provide relief from acute migraines and prevent nausea and vomiting in clinical trials and has anti-psychotic activity.
(1) S.J. Peroutka & S.H. Synder; Am. J. Psychiatry 137, 1518 (1980) | (2) R. Rajamani, et al.; Bioorg. Med. chem. Lett. 15, 1737 (2005) | (3) J.R. Richards, et al.; J. Emerg. Med. 41, 389 (2011) (Review) | (4) J.D. Griffiths, et al.; Cochrane Database Syst.Rev. 9, 1 (2012) | (5) M.C. Thomas, et al.; Ann. Pharmacother. 49, 233 (2015) (Review) | (6) P. Seeman & T. Tallerico; Mol. Psych. 3, 123 (2016)